MGluR long-term depression regulates GluA2 association with COPII vesicles and exit from the endoplasmic reticulum.

ABSTRACT: mGluR long-term depression (mGluR-LTD) is a form of synaptic plasticity induced at excitatory synapses by metabotropic glutamate receptors (mGluRs). mGluR-LTD reduces synaptic strength and is relevant to learning and memory, autism, and sensitization to cocaine; however, the mechanism is not known. Here we show that activation of Group I mGluRs in medium spiny neurons induces trafficking of GluA2 from the endoplasmic reticulum (ER) to the synapse by enhancing GluA2 binding to essential COPII vesicle proteins, Sec23 and Sec13. GluA2 exit from the ER further depends on IP3 and Ryanodine receptor-controlled Ca²⁺ release as well as active translation. Synaptic insertion of GluA2 is coupled to removal of high-conducting Ca²⁺-permeable AMPA receptors from synapses, resultin

SUBMITTER: Pick JE 

PROVIDER: S-EPMC5239995 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature