Structure and Activation of Soluble Guanylyl Cyclase, the Nitric Oxide Sensor.

ABSTRACT:

Significance

Soluble guanylyl/guanylate cyclase (sGC) is the primary receptor for nitric oxide (NO) and is central to the physiology of blood pressure regulation, wound healing, memory formation, and other key physiological activities. sGC is increasingly implicated in disease and is targeted by novel therapeutic compounds. The protein displays a rich evolutionary history and a fascinating signal transduction mechanism, with NO binding to an N-terminal heme-containing domain, which activates the C-terminal cyclase domains. Recent Advances: Crystal structures of individual sGC domains or their bacterial homologues coupled with small-angle x-ray scattering, electron microscopy, chemical cross-linking, and Förster resonance energy transfer measurements are yielding insight into the ov

SUBMITTER: Montfort WR 

PROVIDER: S-EPMC5240008 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature