Helminth-induced Ly6C^hi monocyte-derived alternatively activated macrophages suppress experimental autoimmune encephalomyelitis.

ABSTRACT: Helminths cause chronic infections and affect the immune response to unrelated inflammatory diseases. Although helminths have been used therapeutically to ameliorate inflammatory conditions, their anti-inflammatory properties are poorly understood. Alternatively activated macrophages (AAMϕs) have been suggested as the anti-inflammatory effector cells during helminth infections. Here, we define the origin of AAMϕs during infection with Taenia crassiceps, and their disease-modulating activity on the Experimental Autoimmune Encephalomyelitis (EAE). Our data show two distinct populations of AAMϕs, based on the expression of PD-L1 and PD-L2 molecules, resulting upon T. crassiceps infection. Adoptive transfer of Ly6C⁺ monocytes gave rise to PD-L1⁺/PD-L2⁺, but not

SUBMITTER: Terrazas C 

PROVIDER: S-EPMC5240103 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature