Association of the Intestinal Microbiome with the Development of Neovascular Age-Related Macular Degeneration.

ABSTRACT: Age-related macular degeneration (AMD) is the most frequent cause of blindness in the elderly. There is evidence that nutrition, inflammation and genetic risk factors play an important role in the development of AMD. Recent studies suggest that the composition of the intestinal microbiome is associated with metabolic diseases through modulation of inflammation and host metabolism. To investigate whether compositional and functional alterations of the intestinal microbiome are associated with AMD, we sequenced the gut metagenomes of patients with AMD and controls. The genera Anaerotruncus and Oscillibacter as well as Ruminococcus torques and Eubacterium ventriosum were relatively enriched in patients with AMD, whereas Bacteroides eggerthii was enriched in controls. Patient's intestinal micr

SUBMITTER: Zinkernagel MS 

PROVIDER: S-EPMC5240106 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature