Differential Effects of Vitamins A and D on the Transcriptional Landscape of Human Monocytes during Infection.

ABSTRACT: Vitamin A and vitamin D are essential nutrients with a wide range of pleiotropic effects in humans. Beyond their well-documented roles in cellular differentiation, embryogenesis, tissue maintenance and bone/calcium homeostasis, both vitamins have attracted considerable attention due to their association with-immunological traits. Nevertheless, our knowledge of their immunomodulatory potential during infection is restricted to single gene-centric studies, which do not reflect the complexity of immune processes. In the present study, we performed a comprehensive RNA-seq-based approach to define the whole immunomodulatory role of vitamins A and D during infection. Using human monocytes as host cells, we characterized the differential role of both vitamins upon infection with three different p

SUBMITTER: Klassert TE 

PROVIDER: S-EPMC5240108 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature