Mitochondrial protein import - Functional analysis of the highly diverged Tom22 orthologue of Trypanosoma brucei.

ABSTRACT: The β-barrel protein Tom40 and the α-helically anchored membrane protein Tom22 are the only universally conserved subunits of the protein translocase of the mitochondrial outer membrane (TOM). Tom22 has an N-terminal cytosolic and a C-terminal intermembrane space domain. It occurs in two variants: one typified by the yeast protein which has a cytosolic domain containing a cluster of acidic residues, and a shorter variant typified by the plant protein that lacks this domain. Yeast-type Tom22 functions as a secondary protein import receptor and is also required for the stability of the TOM complex. Much less is known about the more widespread short variant of Tom22, which is also found in the parasitic protozoan Trypanosoma brucei. Here we show that the intermembrane space domain of trypanos

SUBMITTER: Mani J 

PROVIDER: S-EPMC5240110 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature