Dissociable Effects of Cocaine Dependence on Reward Processes: The Role of Acute Cocaine and Craving.

ABSTRACT: The relative impact of chronic vs acute cocaine on dependence-related variability in reward processing in cocaine-dependent individuals (CD) is not well understood, despite the relevance of such effects to long-term outcomes. To dissociate these effects, CD (N=15) and healthy controls (HC; N=15) underwent MRI two times while performing a monetary incentive delay task. Both scans were identical across subjects/groups, except that, in a single-blind, counterbalanced design, CD received intravenous cocaine (30 mg/70 kg) before one session (CD+cocaine) and saline in another (CD+saline). Imaging analyses focused on activity related to anticipatory valence (gain/loss), anticipatory magnitude (small/medium/large), and reinforcing outcomes (successful/unsuccessful). Drug condition (cocaine vs sali

SUBMITTER: Rose EJ 

PROVIDER: S-EPMC5240179 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature