SPAG6 and L1TD1 are transcriptionally regulated by DNA methylation in non-small cell lung cancers.

ABSTRACT:

Background

DNA methylation regulates together with other epigenetic mechanisms the transcriptional activity of genes and is involved in the pathogenesis of malignant diseases including lung cancer. In non-small cell lung cancer (NSCLC) various tumor suppressor genes are already known to be tumor-specifically methylated. However, from the vast majority of a large number of genes which were identified to be tumor-specifically methylated, tumor-specific methylation was unknown so far. Thus, the major aim of this study was to investigate in detail the mechanism(s) responsible for transcriptional regulation of the genes SPAG6 and L1TD1 in NSCLCs.

Methods

We analysed publically available RNA-sequencing data and performed gene expression analyses by RT-PCR. DNA methylation analyses

SUBMITTER: Altenberger C 

PROVIDER: S-EPMC5240214 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature