Single-Blind, Randomized, Controlled Clinical Trial of Exercise in Ambulatory Spinal Muscular Atrophy: Why are the Results Negative?

ABSTRACT:

Background

The benefits of exercise on long-term health and well-being are well established. The possible benefits of exercise in Spinal Muscular Atrophy (SMA) have not been explored in a controlled clinical trial format.

Objective

To assess the effects of exercise on measures of function, strength, and exercise capacity in ambulatory SMA patients.

Methods

Fourteen participants, ages 10-48 years, were randomized to control and exercise cohorts after a 1 month lead-in period. The exercise group received 6 months of intervention. Thereafter, both groups received the intervention for the remaining 12 months. Participants were monitored for a total of 19 months. Exercise included individualized home-based cycling and strengthening. The primary outcome measure was distance

SUBMITTER: Montes J 

PROVIDER: S-EPMC5240606 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature