Ontology highlight
ABSTRACT:
SUBMITTER: Dagdeviren S
PROVIDER: S-EPMC5240661 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Dagdeviren Sezin S Jung Dae Young DY Friedline Randall H RH Noh Hye Lim HL Kim Jong Hun JH Patel Payal R PR Tsitsilianos Nicholas N Inashima Kunikazu K Tran Duy A DA Hu Xiaodi X Loubato Marilia M MM Craige Siobhan M SM Kwon Jung Yeon JY Lee Ki Won KW Kim Jason K JK
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20161103 2
Altered energy balance and insulin resistance are important characteristics of aging. Skeletal muscle is a major site of glucose disposal, and the role of aging-associated inflammation in skeletal muscle insulin resistance remains unclear. To investigate, we examined glucose metabolism in 18-mo-old transgenic mice with muscle-specific overexpression of IL-10 (M<sup>IL10</sup>) and in wild-type mice during hyperinsulinemic-euglycemic clamping. Despite similar fat mass and energy balance, M<sup>IL ...[more]