Impact of mosquito gene drive on malaria elimination in a computational model with explicit spatial and temporal dynamics.

ABSTRACT: The renewed effort to eliminate malaria and permanently remove its tremendous burden highlights questions of what combination of tools would be sufficient in various settings and what new tools need to be developed. Gene drive mosquitoes constitute a promising set of tools, with multiple different possible approaches including population replacement with introduced genes limiting malaria transmission, driving-Y chromosomes to collapse a mosquito population, and gene drive disrupting a fertility gene and thereby achieving population suppression or collapse. Each of these approaches has had recent success and advances under laboratory conditions, raising the urgency for understanding how each could be deployed in the real world and the potential impacts of each. New analyses are needed as ex

SUBMITTER: Eckhoff PA 

PROVIDER: S-EPMC5240713 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature