Tracking solvents in the skin through atomically resolved measurements of molecular mobility in intact stratum corneum.

ABSTRACT: Solvents are commonly used in pharmaceutical and cosmetic formulations and sanitary products and cleansers. The uptake of solvent into the skin may change the molecular organization of skin lipids and proteins, which may in turn alter the protective skin barrier function. We herein examine the molecular effects of 10 different solvents on the outermost layer of skin, the stratum corneum (SC), using polarization transfer solid-state NMR on natural abundance ¹³C in intact SC. With this approach it is possible to characterize the molecular dynamics of solvent molecules when present inside intact SC and to simultaneously monitor the effects caused by the added solvent on SC lipids and protein components. All solvents investigated cause an increased fluidity of SC lipids, with the mo

SUBMITTER: Pham QD 

PROVIDER: S-EPMC5240721 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature