Comparing Human Metapneumovirus and Respiratory Syncytial Virus: Viral Co-Detections, Genotypes and Risk Factors for Severe Disease.

ABSTRACT:

Background

It is unclarified as to whether viral co-detection and human metapneumovirus (HMPV) genotypes relate to clinical manifestations in children with HMPV and lower respiratory tract infection (LRTI), and if the clinical course and risk factors for severe LRTI differ between HMPV and respiratory syncytial virus (RSV).

Methods

We prospectively enrolled hospitalized children aged <16 years with LRTI from 2006 to 2015. Children were clinically examined, and nasopharyngeal aspirates were analyzed using semi-quantitative, real-time polymerase chain reaction tests for HMPV, RSV and 17 other pathogens. HMPV-positive samples were genotyped.

Results

A total of 171 children had HMPV infection. HMPV-infected children with single virus (n = 106) and co-detections (n = 65) h

SUBMITTER: Moe N 

PROVIDER: S-EPMC5240941 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature