Identification and Characterization of Single-Chain Antibodies that Specifically Bind GI Noroviruses.

ABSTRACT: Norovirus infections commonly lead to outbreaks of acute gastroenteritis and spread quickly, resulting in many health and economic challenges prior to diagnosis. Rapid and reliable diagnostic tests are therefore essential to identify infections and to guide the appropriate clinical responses at the point-of-care. Existing tools, including RT-PCR and enzyme immunoassays, pose several limitations based on the significant time, equipment and expertise required to elicit results. Immunochromatographic assays available for use at the point-of-care have poor sensitivity and specificity, especially for genogroup I noroviruses, thus requiring confirmation of results with more sensitive testing methods. Therefore, there is a clear need for novel reagents to help achieve quick and reliable results.

SUBMITTER: Hurwitz AM 

PROVIDER: S-EPMC5240998 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature