Lifetime antipsychotic medication and cognitive performance in schizophrenia at age 43 years in a general population birth cohort.

ABSTRACT: This naturalistic study analysed the association between cumulative lifetime antipsychotic dose and cognition in schizophrenia after an average of 16.5 years of illness. Sixty participants with schizophrenia and 191 controls from the Northern Finland Birth Cohort 1966 were assessed at age 43 years with a neurocognitive test battery. Cumulative lifetime antipsychotic dose-years were collected from medical records and interviews. The association between antipsychotic dose-years and a cognitive composite score based on principal component analysis was analysed using linear regression. Higher lifetime antipsychotic dose-years were significantly associated with poorer cognitive composite score, when adjusted for gender, onset age and lifetime hospital treatment days. The effects of typical and

SUBMITTER: Husa AP 

PROVIDER: S-EPMC5241225 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature