Bromodomain and Extraterminal Protein Inhibitor JQ1 Suppresses Thyroid Tumor Growth in a Mouse Model.

ABSTRACT:

Purpose

New therapeutic approaches are needed for patients with thyroid cancer refractory to radioiodine treatment. An inhibitor of bromodomain and extraterminal domain (BET) proteins, JQ1, shows potent antitumor effects in hematological cancers and solid tumors. To evaluate whether JQ1 is effective against thyroid cancer, we examined antitumor efficacy of JQ1 using the Thrb^PV/PVKras^G12D mouse, a model of anaplastic thyroid cancer.

Experimental design

We treated Thrb^PV/PVKras^G12D mice with vehicle or JQ1 at a dose of 50 mg/kg body weight/day starting at the age of 8 weeks for a 10-week period and monitored thyroid tumor progression.

Results

JQ1 markedly inhibited thyroid tumor growth and prolonged survival of these mice. Glo

SUBMITTER: Zhu X 

PROVIDER: S-EPMC5241246 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature