Financial ties of principal investigators and randomized controlled trial outcomes: cross sectional study.

ABSTRACT:

Objective

 To examine the association between the presence of individual principal investigators' financial ties to the manufacturer of the study drug and the trial's outcomes after accounting for source of research funding.

Design

 Cross sectional study of randomized controlled trials (RCTs).

Setting

 Studies published in "core clinical" journals, as identified by Medline, between 1 January 2013 and 31 December 2013.

Participants

 Random sample of RCTs focused on drug efficacy.

Main outcome measure

 Association between financial ties of principal investigators and study outcome.

Results

 A total of 190 papers describing 195 studies met inclusion criteria. Financial ties between principal investigators and the pharmaceutical industry were present

SUBMITTER: Ahn R 

PROVIDER: S-EPMC5241252 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature