Amiodarone use in patients listed for heart transplant is associated with increased 1-year post-transplant mortality.

ABSTRACT:

Background

Pre-transplant amiodarone use has been postulated as a risk factor for morbidity and mortality after orthotopic heart transplantation (OHT). We assessed pre-OHT amiodarone use and tested the hypothesis that it is associated with impaired post-OHT outcomes.

Methods

We performed a retrospective cohort analysis of adult OHT recipients from the registry of the International Society for Heart and Lung Transplantation (ISHLT). All patients had been transplanted between 2005 and 2013 and were stratified by pre-OHT amiodarone use. We derived propensity scores using logistic regression with amiodarone use as the dependent variable, and assessed the associations between amiodarone use and outcomes with Kaplan-Meier analysis after matching patients 1:1 based on propensity sc

SUBMITTER: Cooper LB 

PROVIDER: S-EPMC5241253 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature