Amplification of R-spondin1 signaling induces granulosa cell fate defects and cancers in mouse adult ovary.

ABSTRACT: R-spondin1 is a secreted regulator of WNT signaling, involved in both embryonic development and homeostasis of adult organs. It can have a dual role, acting either as a mitogen or as a tumor suppressor. During ovarian development, Rspo1 is a key factor required for sex determination and differentiation of the follicular cell progenitors, but is downregulated after birth. In human, increased RSPO1 expression is associated with ovarian carcinomas, but it is not clear whether it is a cause or a consequence of the tumorigenic process. To address the role of Rspo1 expression in adult ovaries, we generated an Rspo1 gain-of-function mouse model. Females were hypofertile and exhibited various ovarian defects, ranging from cysts to ovarian tumors. Detailed phenotypical characterization showed anoma

SUBMITTER: De Cian MC 

PROVIDER: S-EPMC5241429 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature