Genome-Scale Metabolic Modeling of Archaea Lends Insight into Diversity of Metabolic Function.

ABSTRACT: Decades of biochemical, bioinformatic, and sequencing data are currently being systematically compiled into genome-scale metabolic reconstructions (GEMs). Such reconstructions are knowledge-bases useful for engineering, modeling, and comparative analysis. Here we review the fifteen GEMs of archaeal species that have been constructed to date. They represent primarily members of the Euryarchaeota with three-quarters comprising representative of methanogens. Unlike other reviews on GEMs, we specially focus on archaea. We briefly review the GEM construction process and the genealogy of the archaeal models. The major insights gained during the construction of these models are then reviewed with specific focus on novel metabolic pathway predictions and growth characteristics. Metabolic pathway u

SUBMITTER: Thor S 

PROVIDER: S-EPMC5241448 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature