Non-pathogenic tissue-resident CD8⁺ T cells uniquely accumulate in the brains of lupus-prone mice.

ABSTRACT: Severe lupus often includes psychiatric and neurological sequelae, although the cellular contributors to CNS disease remain poorly defined. Using intravascular staining to discriminate tissue-localized from blood-borne cells, we find substantial accumulation of CD8⁺ T cells relative to other lymphocytes in brain tissue, which correlates with lupus disease and limited neuropathology. This is in contrast to all other affected organs, where infiltrating CD4⁺ cells are predominant. Brain-infiltrating CD8⁺ T cells represent an activated subset of those found in the periphery, having a resident-memory phenotype (CD69⁺CD122^-PD1⁺CD44⁺CD62L^-) and expressing adhesion molecules (VLA-4⁺LFA-1⁺)

SUBMITTER: Morawski PA 

PROVIDER: S-EPMC5241651 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature