Addressing the Functional Determinants of FAK during Ciliogenesis in Multiciliated Cells.

ABSTRACT: We previously identified focal adhesion kinase (FAK) as an important regulator of ciliogenesis in multiciliated cells. FAK and other focal adhesion (FA) proteins associate with the basal bodies and their striated rootlets and form complexes named ciliary adhesions (CAs). CAs display similarities with FAs but are established in an integrin independent fashion and are responsible for anchoring basal bodies to the actin cytoskeleton during ciliogenesis as well as in mature multiciliated cells. FAK down-regulation leads to aberrant ciliogenesis due to impaired association between the basal bodies and the actin cytoskeleton, suggesting that FAK is an important regulator of the CA complex. However, the mechanism through which FAK functions in the complex is not clear, and in this study we examin

SUBMITTER: Antoniades I 

PROVIDER: S-EPMC5241726 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature