Ontology highlight
ABSTRACT:
SUBMITTER: Moretti S
PROVIDER: S-EPMC5241810 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Nature communications 20170116
T helper 9 (Th9) cells contribute to lung inflammation and allergy as sources of interleukin-9 (IL-9). However, the mechanisms by which IL-9/Th9 mediate immunopathology in the lung are unknown. Here we report an IL-9-driven positive feedback loop that reinforces allergic inflammation. We show that IL-9 increases IL-2 production by mast cells, which leads to expansion of CD25<sup>+</sup> type 2 innate lymphoid cells (ILC2) and subsequent activation of Th9 cells. Blocking IL-9 or inhibiting CD117 ...[more]