Ontology highlight
ABSTRACT:
SUBMITTER: Sacramento CQ
PROVIDER: S-EPMC5241873 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Scientific reports 20170118
Zika virus (ZIKV) is a member of the Flaviviridae family, along with other agents of clinical significance such as dengue (DENV) and hepatitis C (HCV) viruses. Since ZIKV causes neurological disorders during fetal development and in adulthood, antiviral drugs are necessary. Sofosbuvir is clinically approved for use against HCV and targets the protein that is most conserved among the members of the Flaviviridae family, the viral RNA polymerase. Indeed, we found that sofosbuvir inhibits ZIKV RNA p ...[more]