Lithium Accumulates in Neurogenic Brain Regions as Revealed by High Resolution Ion Imaging.

ABSTRACT: Lithium (Li) is a potent mood stabilizer and displays neuroprotective and neurogenic properties. Despite extensive investigations, the mechanisms of action have not been fully elucidated, especially in the juvenile, developing brain. Here we characterized lithium distribution in the juvenile mouse brain during 28 days of continuous treatment that result in clinically relevant serum concentrations. By using Time-of-Flight Secondary Ion Mass Spectrometry- (ToF-SIMS) based imaging we were able to delineate temporospatial lithium profile throughout the brain and concurrent distribution of endogenous lipids with high chemical specificity and spatial resolution. We found that Li accumulated in neurogenic regions and investigated the effects on hippocampal neurogenesis. Lithium increased prolifer

SUBMITTER: Zanni G 

PROVIDER: S-EPMC5241875 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature