Migraine Susceptibility Genes in Han Chinese of Fujian Province.

ABSTRACT:

Background and purpose

Five single-nucleotide polymorphisms (SNPs) (rs4379368, rs10504861, rs10915437, rs12134493 and rs13208321) were recently identified in a Western population with migraine. These migraine-associated SNPs have not been evaluated in a Han Chinese population. This study investigated the associations of specific SNPs with migraine in a Han population.

Methods

This was a case-control study of Han Chinese residing in Fujian Province. Polymerase chain reaction-restriction-fragment-length polymorphism analysis and direct sequencing were used to characterize the relationships of SNPs in a control group of 200 subjects and in a migraine group of 201 patients.

Results

The frequencies of the five SNPs did not differ between patients with migraine and healthy

SUBMITTER: Lin QF 

PROVIDER: S-EPMC5242144 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature