Oral Tolerance Induced by OVA Intake Ameliorates TNBS-Induced Colitis in Mice.

ABSTRACT:

Introduction

Literature data have shown that the consumption of dietary proteins may cause modulatory effects on the host immune system, process denominated oral tolerance by bystander suppression. It has been shown that the bystander suppression induced by dietary proteins can improve inflammatory diseases such as experimental arthritis. Here, we evaluated the effects of oral tolerance induced by ingestion of ovalbumin (OVA) on TNBS-induced colitis in mice, an experimental model for human Crohn's disease.

Methods and results

Colitis was induced in BALB/c mice by instilling a single dose of TNBS (100 mg/kg) in ethanol into the colon. Tolerized mice received OVA (4mg/mL) dissolved in the drinking water for seven consecutive days, prior to or concomitantly with the intrarectal

SUBMITTER: Paiatto LN 

PROVIDER: S-EPMC5242488 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature