Acute Inactivation of Primary Auditory Cortex Causes a Sound Localisation Deficit in Ferrets.

ABSTRACT: The objective of this study was to demonstrate the efficacy of acute inactivation of brain areas by cooling in the behaving ferret and to demonstrate that cooling auditory cortex produced a localisation deficit that was specific to auditory stimuli. The effect of cooling on neural activity was measured in anesthetized ferret cortex. The behavioural effect of cooling was determined in a benchmark sound localisation task in which inactivation of primary auditory cortex (A1) is known to impair performance. Cooling strongly suppressed the spontaneous and stimulus-evoked firing rates of cortical neurons when the cooling loop was held at temperatures below 10°C, and this suppression was reversed when the cortical temperature recovered. Cooling of ferret auditory cortex during behavioural testing

SUBMITTER: Wood KC 

PROVIDER: S-EPMC5242495 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature