Dysregulated ErbB4 Splicing in Schizophrenia: Selective Effects on Parvalbumin Expression.

ABSTRACT:

Objective

Alternative splicing of ErbB4 transcripts is dysregulated in the dorsolateral prefrontal cortex in schizophrenia. ErbB4 regulates the activity of parvalbumin interneurons, and therefore dysregulated ErbB4 splicing could contribute to lower parvalbumin interneuron activity and consequently lower parvalbumin levels in schizophrenia. However, ErbB4 is also present in calretinin interneurons, which are not affected in schizophrenia. Therefore, the authors hypothesized that dysregulated ErbB4 splicing occurs selectively in parvalbumin interneurons and is associated with lower parvalbumin levels in schizophrenia.

Method

Tissue samples enriched in calretinin and parvalbumin interneurons were laser microdissected from dorsolateral prefrontal cortex layers 2 and 4, respecti

SUBMITTER: Chung DW 

PROVIDER: S-EPMC5242561 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature