The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism.
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SUBMITTER: Spanogiannopoulos P
PROVIDER: S-EPMC5243131 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
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The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism.
Spanogiannopoulos Peter P Bess Elizabeth N EN Carmody Rachel N RN Turnbaugh Peter J PJ
Nature reviews. Microbiology 20160314 5
Although the importance of human genetic polymorphisms in therapeutic outcomes is well established, the role of our 'second genome' (the microbiome) has been largely overlooked. In this Review, we highlight recent studies that have shed light on the mechanisms that link the human gut microbiome to the efficacy and toxicity of xenobiotics, including drugs, dietary compounds and environmental toxins. Continued progress in this area could enable more precise tools for predicting patient responses a ...[more]
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