The influence of 21-gene recurrence score assay on chemotherapy use in a population-based sample of breast cancer patients.

ABSTRACT:

Purpose

To quantify the influence of RS assay on changing chemotherapy plans in a general practice setting using causal inference methods.

Methods

We surveyed 3880 newly diagnosed breast cancer patients in Los Angeles and Georgia in 2013-14. We used inverse propensity weighting and multiple imputations to derive complete information for each patient about treatment status with and without testing.

Results

A half of the 1545 women eligible for testing (ER+ or PR+, HER2-, and stage I-II) received RS. We estimate that 30% (95% confidence interval (CI) 10-49%) of patients would have changed their treatment selections after RS assay, with 10% (CI 0-20%) being encouraged to undergo chemotherapy and 20% (CI 10-30%) being discouraged from chemotherapy. The subgroups whose tre

SUBMITTER: Li Y 

PROVIDER: S-EPMC5243200 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature