Perivascular PDGFR-β is an independent marker for prognosis in renal cell carcinoma.

ABSTRACT:

Background

Renal cell carcinoma (RCC) is a highly vascularised tumour, where anti-angiogenic treatment with multi-tyrosine-kinase-inhibitor, is used for first-line treatment of metastatic disease. Variations in vascular characteristics are likely to contribute to variations in intrinsic aggressiveness of the disease. Emerging studies are identifying perivascular status, including perivascular PDGFR-β, as a determinant of prognosis in other tumour types.

Methods

This work explored the impact on prognosis of vascular characteristics in RCC through analyses of a population-based collection of tumours from surgery-alone-treated patients. The quantitative data from a panel of vascular metrics were obtained through computerised image analysis of sections double-stained for express

SUBMITTER: Frodin M 

PROVIDER: S-EPMC5243993 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature