Divergence of spatial gene expression profiles following species-specific gene duplications in human and mouse.

ABSTRACT: To examine the process by which duplicated genes diverge in function, we studied how the gene expression profiles of orthologous gene sets in human and mouse are affected by the presence of additional recent species-specific paralogs. Gene expression profiles were compared across 16 homologous tissues in human and mouse using microarray data from the Gene Expression Atlas for 1575 sets of orthologs including 250 with species-specific paralogs. We find that orthologs that have undergone recent duplication are less likely to have strongly correlated expression profiles than those that remain in a one-to-one relationship between human and mouse. There is a general trend for paralogous genes to become more specialized in their expression patterns, with decreased breadth and increased specifici

SUBMITTER: Huminiecki L 

PROVIDER: S-EPMC524410 | biostudies-literature | 2004 Oct

REPOSITORIES: biostudies-literature