Oral Administration of a Select Mixture of Bacillus Probiotics Affects the Gut Microbiota and Goblet Cell Function following Escherichia coli Challenge in Newly Weaned Pigs of Genotype MUC4 That Are Supposed To Be Enterotoxigenic E. coli F4ab/ac Receptor Negative.

ABSTRACT: Structural disruption of the gut microbiota and impaired goblet cell function are collateral etiologic factors in enteric diseases. Low, moderate, or high doses of a Bacillus licheniformis-B. subtilis mixture (BLS mix) were orally administered to piglets of genotype MUC4 that are supposed to be F4-expressing enterotoxigenic Escherichia coli strain (F4⁺ ETEC) F4ab/ac receptor negative (i.e., MUC4-resistant piglets) for 1 week before F4⁺ ETEC challenge. The luminal contents were collected from the mucosa of the colon on day 8 after F4⁺ ETEC challenge. The BLS mix attenuated E. coli-induced expansion of Bacteroides uniformis, Eubacterium eligens, Acetanaerobacterium, and Sporobacter populations. Clostridium and Turicibacter populations increased following F4

SUBMITTER: Zhang W 

PROVIDER: S-EPMC5244294 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature