Lasing in Live Mitotic and Non-Phagocytic Cells by Efficient Delivery of Microresonators.

ABSTRACT: Reliable methods to individually track large numbers of cells in real time are urgently needed to advance our understanding of important biological processes like cancer metastasis, neuronal network development and wound healing. It has recently been suggested to introduce microscopic whispering gallery mode lasers into the cytoplasm of cells and to use their characteristic, size-dependent emission spectrum as optical barcode but so far there is no evidence that this approach is generally applicable. Here, we describe a method that drastically improves intracellular delivery of resonators for several cell types, including mitotic and non-phagocytic cells. In addition, we characterize the influence of resonator size on the spectral characteristics of the emitted laser light and identify an

SUBMITTER: Schubert M 

PROVIDER: S-EPMC5244359 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature