A single identified glomerulus in the zebrafish olfactory bulb carries the high-affinity response to death-associated odor cadaverine.

ABSTRACT: The death-associated odor cadaverine, generated by bacteria-mediated decarboxylation of lysine, has been described as the principal activator of a particular olfactory receptor in zebrafish, TAAR13c. Low concentrations of cadaverine activated mainly TAAR13c-expressing olfactory sensory neurons, suggesting TAAR13c as an important element of the neuronal processing pathway linking cadaverine stimulation to a strongly aversive innate behavioral response. Here, we characterized the initial steps of this neuronal pathway. First we identified TAAR13c-expressing cells as ciliated neurons, equivalent to the situation for mammalian taar genes, which shows a high degree of conservation despite the large evolutionary distance between teleost fishes and mammals. Next we identified the target area of c

SUBMITTER: Dieris M 

PROVIDER: S-EPMC5244376 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature