Transcriptional profiling of olfactory system development identifies distal antenna as a regulator of subset of neuronal fates.

ABSTRACT: Drosophila uses 50 different olfactory receptor neuron (ORN) classes that are clustered within distinct sensilla subtypes to decipher their chemical environment. Each sensilla subtype houses 1-4 ORN identities that arise through asymmetric divisions of a single sensory organ precursor (SOP). Despite a number of mutational studies investigating the regulation of ORN development, a majority of the transcriptional programs that lead to the different ORN classes in the developing olfactory system are unknown. Here we use transcriptional profiling across the time series of antennal development to identify novel transcriptional programs governing the differentiation of ORNs. We surveyed four critical developmental stages of the olfactory system: 3rd instar larval (prepatterning), 8 hours after p

SUBMITTER: Barish S 

PROVIDER: S-EPMC5244397 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature