Cofilin Regulates Nuclear Architecture through a Myosin-II Dependent Mechanotransduction Module.

ABSTRACT: Structural features of the nucleus including shape, size and deformability impact its function affecting normal cellular processes such as cell differentiation and pathological conditions such as tumor cell migration. Despite the fact that abnormal nuclear morphology has long been a defining characteristic for diseases such as cancer relatively little is known about the mechanisms that control normal nuclear architecture. Mounting evidence suggests close coupling between F-actin cytoskeletal organization and nuclear morphology however, mechanisms regulating this coupling are lacking. Here we identify that Cofilin/ADF-family F-actin remodeling proteins are essential for normal nuclear structure in different cell types. siRNA mediated silencing of Cofilin/ADF provokes striking nuclear defect

SUBMITTER: Wiggan O 

PROVIDER: S-EPMC5244421 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature