Effectiveness and Tolerability of Different Recommended Doses of PPIs and H₂RAs in GERD: Network Meta-Analysis and GRADE system.

ABSTRACT: Proton pump inhibitors (PPIs) and histamine-2-receptor antagonists (H₂RAs) are used for gastro-esophageal reflux disease (GERD); however, the clinical evidence for treatment is poor. We evaluated the effectiveness and tolerability of different doses of PPIs, H₂RAs and placebo in adults with GERD. Six online databases were searched through September 1, 2016. All related articles were included and combined with a Bayesian network meta-analysis from randomized controlled trials (RCTs). The GRADE systems were employed to assess the main outcome. Ninety-eight RCTs were identified, which included 45,964 participants. Our analysis indicated that the full/standard dose of esomeprazole at 40 mg per day was the most efficient in healing among nine different dosages of PPIs and

SUBMITTER: Zhang C 

PROVIDER: S-EPMC5244481 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature