Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus.

ABSTRACT:

Background

In 2014, Western Africa experienced an unanticipated explosion of Ebola virus infections. What distinguishes fatal from non-fatal outcomes remains largely unknown, yet is key to optimising personalised treatment strategies. We used transcriptome data for peripheral blood taken from infected and convalescent recovering patients to identify early stage host factors that are associated with acute illness and those that differentiate patient survival from fatality.

Results

The data demonstrate that individuals who succumbed to the disease show stronger upregulation of interferon signalling and acute phase responses compared to survivors during the acute phase of infection. Particularly notable is the strong upregulation of albumin and fibrinogen genes, which suggest s

SUBMITTER: Liu X 

PROVIDER: S-EPMC5244546 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature