Genome-wide standing variation facilitates long-term response to bidirectional selection for antibody response in chickens.

ABSTRACT:

Background

Long-term selection experiments provide a powerful approach to gain empirical insights into adaptation, allowing researchers to uncover the targets of selection and infer their contributions to the mode and tempo of adaptation. Here we implement a pooled genome re-sequencing approach to investigate the consequences of 39 generations of bidirectional selection in White Leghorn chickens on a humoral immune trait: antibody response to sheep red blood cells.

Results

We observed wide genome involvement in response to this selection regime. Many genomic regions were highly differentiated resulting from this experimental selection regime, an involvement of up to 20% of the chicken genome (208.8 Mb). While genetic drift has certainly contributed to this, we implement gene

SUBMITTER: Lillie M 

PROVIDER: S-EPMC5244587 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature