Microstructural models for diffusion MRI in breast cancer and surrounding stroma: an ex vivo study.

ABSTRACT: The diffusion signal in breast tissue has primarily been modelled using apparent diffusion coefficient (ADC), intravoxel incoherent motion (IVIM) and diffusion tensor (DT) models, which may be too simplistic to describe the underlying tissue microstructure. Formalin-fixed breast cancer samples were scanned using a wide range of gradient strengths, durations, separations and orientations. A variety of one- and two-compartment models were tested to determine which best described the data. Models with restricted diffusion components and anisotropy were selected in most cancerous regions and there were no regions in which conventional ADC or DT models were selected. Maps of ADC generally related to cellularity on histology, but maps of parameters from more complex models suggest that both over

SUBMITTER: Bailey C 

PROVIDER: S-EPMC5244665 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature