Design, synthesis and characterization of linear unnatural amino acids for skin moisturization.

ABSTRACT:

Objectives

This work aimed to design, synthesize and characterize replacement natural moisturizing factor (NMF) composed of modified hygroscopic linear amino acids to pre-empt or repair skin barrier dysfunction.

Methods

Following synthesis and characterization, thermo-gravimetric analysis and quantum mechanics molecular modelling quantified and depicted water binding to the new compounds. Deliquescence relative humidity demonstrated the water-scavenging ability of the compounds, whereas snake skin moisturizing studies showed they increased water uptake into snake skin.

Results

From thermal analysis, N-hydroxyglycine showed greatest water-holding capacity followed by N-hydroxyserine, l-homoserine and α-hydroxyglycine; coupled with quantum mechanics molecular modelling,

SUBMITTER: Arezki NR 

PROVIDER: S-EPMC5244679 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature