Characterization of an endogenous retrovirus class in elephants and their relatives.

ABSTRACT:

Background

Endogenous retrovirus-like elements (ERV-Ls, primed with tRNA leucine) are a diverse group of reiterated sequences related to foamy viruses and widely distributed among mammals. As shown in previous investigations, in many primates and rodents this class of elements has remained transpositionally active, as reflected by increased copy number and high sequence diversity within and among taxa.

Results

Here we examine whether proviral-like sequences may be suitable molecular probes for investigating the phylogeny of groups known to have high element diversity. As a test we characterized ERV-Ls occurring in a sample of extant members of superorder Uranotheria (Asian and African elephants, manatees, and hyraxes). The ERV-L complement in this group is even more diverse

SUBMITTER: Greenwood AD 

PROVIDER: S-EPMC524511 | biostudies-literature | 2004 Oct

REPOSITORIES: biostudies-literature