Chemical exposures and risk of acute myeloid leukemia and myelodysplastic syndromes in a population-based study.

ABSTRACT: Benzene exposure is one of the few well-established risk factors for myeloid malignancy. Exposure to other chemicals has been inconsistently associated with hematologic malignancies. We evaluated occupational and residential chemical exposures as risk factors for acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) using population-based data. AML and MDS cases were identified by the Minnesota Cancer Surveillance System. Controls were identified through the Minnesota driver's license/identification card list. Chemical exposures were measured by self-report. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CI). We included 265 MDS cases, 420 AML cases and 1388 controls. We observed significant associations between both MDS a

SUBMITTER: Poynter JN 

PROVIDER: S-EPMC5245124 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature