The spread of hepatitis C virus genotype 1a in North America: a retrospective phylogenetic study.

ABSTRACT:

Background

The timing of the initial spread of hepatitis C virus genotype 1a in North America is controversial. In particular, how and when hepatitis C virus reached extraordinary prevalence in specific demographic groups remains unclear. We quantified, using all available hepatitis C virus sequence data and phylodynamic methods, the timing of the spread of hepatitis C virus genotype 1a in North America.

Methods

We screened 45 316 publicly available sequences of hepatitis C virus genotype 1a for location and genotype, and then did phylogenetic analyses of available North American sequences from five hepatitis C virus genes (E1, E2, NS2, NS4B, NS5B), with an emphasis on including as many sequences with early collection dates as possible. We inferred the historical population

SUBMITTER: Joy JB 

PROVIDER: S-EPMC5245154 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature