Polymorphisms in HTR2A and DRD4 Predispose to Smoking and Smoking Quantity.

ABSTRACT:

Background

Genes encoding the receptors involved in the dopaminergic and serotonergic pathways are potential candidates in the mechanisms of nicotine addiction.

Aims

To identify genetic variants in the promoter regions and exons of the DRD4 and HTR2A genes associated with tobacco smoking and the degree of nicotine addiction in Mexican mestizos.

Methods

The study included 438 non-smokers (NS) and 1,157 current smokers, ranked based on their consumption of cigarettes per day (cpd): 574 heavy smokers (HS, >20 cpd) and 583 light smokers (LS, 1-10 cpd). Genotyping was performed for 4 and 8 single nucleotide polymorphisms (SNPs) in the DRD4 and HTR2A genes, respectively.

Results

The C allele of rs1800955 in DRD4 was found to be associated with cigarette smoking in th

SUBMITTER: Perez-Rubio G 

PROVIDER: S-EPMC5245876 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature