The Antiviral RNAi Response in Vector and Non-vector Cells against Orthobunyaviruses.

ABSTRACT:

Background

Vector arthropods control arbovirus replication and spread through antiviral innate immune responses including RNA interference (RNAi) pathways. Arbovirus infections have been shown to induce the exogenous small interfering RNA (siRNA) and Piwi-interacting RNA (piRNA) pathways, but direct antiviral activity by these host responses in mosquito cells has only been demonstrated against a limited number of positive-strand RNA arboviruses. For bunyaviruses in general, the relative contribution of small RNA pathways in antiviral defences is unknown.

Methodology/principal findings

The genus Orthobunyavirus in the Bunyaviridae family harbours a diverse range of mosquito-, midge- and tick-borne arboviruses. We hypothesized that differences in the antiviral RNAi response in

SUBMITTER: Dietrich I 

PROVIDER: S-EPMC5245901 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature