Myelin-targeted, texaphyrin-based multimodal imaging agent for magnetic resonance and optical imaging.

ABSTRACT: Reliable methods of imaging myelin are essential to investigate the causes of demyelination and to study drugs that promote remyelination. Myelin-specific compounds can be developed into imaging probes to detect myelin with various imaging techniques. The development of multimodal myelin-specific imaging probes enables the use of orthogonal imaging techniques to accurately visualize myelin content and validate experimental results. Here, we describe the synthesis and application of multimodal myelin-specific imaging agents for light microscopy and magnetic resonance imaging. The imaging agents were synthesized by incorporating the structural features of luxol fast blue MBS, a myelin-specific histological stain, into texaphyrins coordinated to Gd^III . These new complexes demonstr

SUBMITTER: Vithanarachchi SM 

PROVIDER: S-EPMC5247309 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature