Requirement of Gα_q/Gα₁₁ Signaling in the Preservation of Mouse Intestinal Epithelial Homeostasis.

ABSTRACT:

Background & aims

Proliferation, differentiation, and morphogenesis of the intestinal epithelium are tightly regulated by a number of molecular pathways. Coordinated action of intestine is achieved by gastrointestinal hormones, most of which exert these actions through G-protein-coupled receptors. We herein investigated the role of Gα_q/11-mediated signaling in intestinal homeostasis.

Methods

Intestinal tissues from control (Gnaq^flox/floxGna11^+/+ ), Int-G_q knock-out (KO) (VilCre^+/-Gnaq^flox/floxGna11^+/+ ), G₁₁ KO (Gnaq^flox/floxGna11^-/- ), and Int-G_q/G₁₁

SUBMITTER: Watanabe N 

PROVIDER: S-EPMC5247319 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature